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Accession number;99A0540725
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| Title;Cardiovascular Effects of Bucladesine Ointment in the Rat Experimental Skin Burn Model: Pharmacokinetic-Pharmacodynamic Relationships. |
| Author;
KASAI YOSHIO
(Daiichiseiyaku Anzenseiken)
KITANO YUTAKA
(Daiichiseiyaku Anzenseiken)
MAKINO MITSUHIRO
(Daiichiseiyaku Anzenseiken)
KOMIYAMA CHIKA
(Daiichiseiyaku Anzenseiken)
TAKASUNA KIYOSHI
(Daiichiseiyaku Anzenseiken)
NAKASHIMA KENJI
(Daiichiseiyaku Anzenseiken)
MAFUNE EIICHI
(Daiichiseiyaku Sozaiken)
KIMURA YUKO
(Daiichi Pharm. Co., Ltd.)
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Journal Title;Pharmacometrics
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Journal Code:S0617A
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ISSN:0300-8533
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VOL.57;NO.1/2;PAGE.39-44(1999)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Cardiovascular effects of bucladesine ointment containing 3.0% dibutyryl cyclic AMP(DBcAMP) were investigated using rats with abdominal skin burn. On the 1st day postburn, bucladesine ointment did not affect blood pressure or heart rate at doses of 300 and 600mg/site, and plasma concentrations of DBcAMP were undetectable level and 0.6.MU.g/ml, respectively. On the 9-15th days postburn (after shedding of the scab), bucladesine ointment showed no cardiovascular effect at a dose of 300mg/site, but it significantly decreased blood pressure and slightly decreased heart rate at a dose of 600mg/site. Plasma concentrations of DBcAMP were 0.3 and 1.7.MU.g/ml at 120min after treatment with 300 and 600mg/site, respectively. These results suggest that bucladesine ointment could be absorbed into bloodstream from skin burn after shodding scab and could induce cardiovascular effects. (author abst.) |
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