A Case of Primary Sjoegren's Syndrome Presenting with Aseptic Meningoencephalitis Associated with Sarcoidosis.
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Accession number;99A0551111
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| Title;A Case of Primary Sjoegren's Syndrome Presenting with Aseptic Meningoencephalitis Associated with Sarcoidosis. |
| Author;
NISHIDA HIROSHI
(Gifu Prefect. Gifu Hosp.)
TANAKA YUJI
(Gifu Prefect. Gifu Hosp.)
YASUDA SHIGEO
(Gifu Prefect. Gifu Hosp.)
YAMADA MASAO
(Gifu Prefect. Gifu Hosp.)
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Journal Title;Brain Nerve
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Journal Code:Z0685A
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ISSN:0006-8969
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VOL.51;NO.4;PAGE.349-352(1999)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 64-year-old Japanese woman with sarcoidosis and primary Sjoegren's syndrome was admitted to our hospital in January 1998 for consciousness loss. Physical examination revealed meningeal signs and hyperreflexia in the lower limbs. Laboratory investigations showed hypergammaglobulinemia and high titers of autoantibodies such as RF, ANA, anti SS-A and SS-B antibody. In addition, she had keratoconjunctivitis, and an apple-tree pattern was observed in sialography, but serum ACE was normal. In the cerebrospinal fluid(CSF), the cell count, total protein, and interleukin 6(IL-6) were increased, but ACE in CSF was normal. We diagnosed the case as primary Sjoegren's syndrome presenting with aseptic meningoencephalitis. After treatment with prednisolone, her manifestations and CSF findings including IL-6 resolved. Therefore, the level of IL-6 in CSF may be an indicator for the activity of primary Sjoegren's syndrome associated with central nervous manifestations. (author abst.) |
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