Synthesis of trifluoromethylketones from .ALPHA.-amino acids and its use for preparation of trifluoromethyl-substituted heterocycles.
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Accession number;99A0711827
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| Title;Synthesis of trifluoromethylketones from .ALPHA.-amino acids and its use for preparation of trifluoromethyl-substituted heterocycles. |
| Author;
KAWASE MASAMI
(Josai Univ., Fac. of Pharm. Sci.)
HIRABAYASHI MICHITAKA
(Josai Univ., Fac. of Pharm. Sci.)
MIYAMAE HIROSHI
(Josai Univ., Fac. of Sci.)
YAMAMOTO KATSUMI
(Josai Univ., Fac. of Pharm. Sci.)
SAITO SETSUO
(Josai Univ., Fac. of Pharm. Sci.)
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Journal Title;Fusso Kagaku Toronkai Koen Yoshishu
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Journal Code:F0135B
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ISSN:
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VOL.22nd;NO.;PAGE.32-33(1998)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Treatment of N-alkoxycarbonyl-N-alkyl-.ALPHA.-amino acids or N-alkoxycarbonylprolines with TFAA afforded .ALPHA.-aminotrifluoromethylketones and 4-trifluoroacetyl-2,3-dihydropyrroles (CF3-DHP), respectively. CF3-DHP was used as a building block in synthesis of trifluoromethyl-substituted heterocycles, bearing as aminoethyl side chain. The reaction sequence represents a special type of ring transformation, termed "ring chain transformation", where the starting ring becomes a chain in the product. (author abst.) |
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