Science Links Japan | A novel synthesis of fluorinated amino acids and their derivatives via intermolecular addition-elimination of enolates.

A novel synthesis of fluorinated amino acids and their derivatives via intermolecular addition-elimination of enolates.

Accession number;99A0711830

Title;A novel synthesis of fluorinated amino acids and their derivatives via intermolecular addition-elimination of enolates.

Author; HAO J (Okayama Univ., Fac. of Eng.) OKURA HIRONARI (Okayama Univ., Fac. of Eng.) AMII HIDEKI (Okayama Univ., Fac. of Eng.) UNEYAMA KENJI (Okayama Univ., Fac. of Eng.)

Journal Title;Fusso Kagaku Toronkai Koen Yoshishu

Journal Code:F0135B

ISSN:

VOL.22nd;NO.;PAGE.38-39(1998)

Figure&Table&Reference;

Pub. Country;Japan

Language;Japanese

Abstract;The methodology for the construction of .BETA.-fluorinated amino acids and their derivatives via intermolecular addition-elimination of enolates is reported. The intramolecular rearrangement of trifluoroacetimidyl derivatives have been achieved under the basic conditions. The reactions which underwent the Wittig type rearrangement is only in the case of iminoether (X=O) compounds, the nitrogen (X=N) and sulfur (X=S) derivatives underwent different pathways and formed the unexpected compounds, respectively. The subsequent transformation of these compounds resulted in the formation of designed fluorinated amino acid derivatives. (author abst.)

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