Science Links Japan | Lipase-catalyzed resoution of fluorine-containing cyanohydrin derivatives and its application to the synthesis.

Lipase-catalyzed resoution of fluorine-containing cyanohydrin derivatives and its application to the synthesis.

Accession number;99A0711831

Title;Lipase-catalyzed resoution of fluorine-containing cyanohydrin derivatives and its application to the synthesis.

Author; SAKAI TAKASHI (Okayama Univ., Fac. of Eng.) MIKI YASUSHI (Okayama Univ., Fac. of Eng.) TSUBOI MASASHI (Okayama Univ., Fac. of Eng.) EMA TADASHI (Okayama Univ., Fac. of Eng.) UTAKA MASANORI (Okayama Univ., Fac. of Eng.)

Journal Title;Fusso Kagaku Toronkai Koen Yoshishu

Journal Code:F0135B

ISSN:

VOL.22nd;NO.;PAGE.40-41(1998)

Figure&Table&Reference;

Pub. Country;Japan

Language;Japanese

Abstract;Enantiomerically pure (S)- and (R)-2-hydroxy-2-(pentafluorophenyl)acetonitriles was obtained by use of lipase-catalyzed kinetic resolution. This compound was carefully transformed (TBDMSOTf, DMAP) into its TBDMS-ether as a new chiral fluorinated building brock without loss of the optical purity, and into naproxen ester for X-ray analysis to determine the absolute configuration. Interestingly, the crystal structure of naproxen ester showed the stacking ability of pentafluorophenyl group with naphthyl group. (author abst.)

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