|
Accession number;99A0711832
|
| Title;Imaging of phosphodiesterase type 4 by fluorine-18 labeled KF19316. |
| Author;
HATANO KENTARO
(Kokuritsuchojuiryokense)
SAKIYAMA YOJIRO
(Kokuritsuchojuiryokense)
SUZUKI MITSURU
(Kokuritsuchojuiryokense)
KAWASUMI YASUHIRO
(Kokuritsuchojuiryokense)
KATO TAKASHI
(Kokuritsuchojuiryokense)
KAWAKITA TAKASHI
(Kyowa Hakko Kogyo Co., Ltd.)
SUZUKI FUMIO
(Kyowa Hakko Kogyo Co., Ltd.)
ITO KENGO
(Kokuritsuchojuiryokense)
|
Journal Title;Fusso Kagaku Toronkai Koen Yoshishu
|
Journal Code:F0135B
|
ISSN:
|
|
VOL.22nd;NO.;PAGE.42-43(1998)
|
| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Phosdiesterase type4 (PDE4) which selectively hydrolyzes cyclic AMP might play an important role in natural transmission. PDE4 inhibitor, KF19316, was labeled by fluorin-18 for the noninvasive imaging of cAMP dependent neural activity by positron emission tomography. was obtained from KF19316 and 4-[18F]fluorobenzylidodide (FBI) which was prepared by 3-step synthesis from [18F]fluoride. Radiochemical yield of [18F]KF19316 was ranged from 80 to 90 % based on total FBI. The regional brain distribution of [18F]KF19316 were consistent to the [3H]rolipram binding sites. (author abst.) |
|
|
|
Related Articles;
|
