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Accession number;99A0562722
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| Title;Cholesterol-Lowering Effects of Isolated Soybean Protein Hydrolyzate with Bound Phospholipids in Rats. |
| Author;
HORI GORO
(Kyowahakkokogyo Tsukubaken)
YAMAMOTO KAZUHIRO
(Kyowahakkokogyo Tsukubaken)
MORISHITA KOJI
(Kyowahakkokogyo Tsukubaken)
MUKAWA SAORI
(Kyowahakkokogyo Tsukubaken)
KAMIYA TOSHIKAZU
(Kyowahakkokogyo Tsukubaken)
NAGAOKA SATOSHI
(Gifu Univ., Fac. of Agric.)
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Journal Title;Journal of Japanese Society of Nutrition and Food Science
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Journal Code:F0624A
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ISSN:0287-3516
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VOL.52;NO.3;PAGE.135-145(1999)
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| Figure&Table&Reference;FIG.3, TBL.7, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A soybean protein pepsin-hydrolyzate with bound phospholipids (SPHP-p) was prepared, and its effects (at 1-20% in the diet) on cholesterol levels were examined in rats. All the rats were fed a cholesterol-enriched diet for 10 days, followed by the experimental diets for a further 9 days. SPHP-p dose-dependently reduced the levels of serum and liver cholesterol which had already accumulated within the body. The cholesterol-reducing effect of SPHP-p was more marked in the cholesterol-enriched (0.5%) diet group than in the cholesterol-free diet group. Another preparation from soybean protein hydrolyzed with microbial protease instead of pepsin (SPHP-s) was also examined, and was shown to suppress cholesterol absorption by Caco-2 cells in vitro, and to reduce the levels of serum and liver cholesterol in rats fed a cholesterol-enriched diet with a potency comparable to that of SPHP-p. These results indicate that both SPHP-p and SPHP-s can not only suppress the accumulation of exogenous cholesterol, but also reduce cholesterol which has already accumulated within the body by suppressing the absorption of cholesterol in the intestinal tract. (author abst.) |
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