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Accession number;99A0465596
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| Title;The Inhibitory Action of Biguanide on Increased Glomerular Filtration Rate after Ingestion of Protein. |
| Author;
NAKAMURA HIROSHI
(Nakamura Iin)
NAKAGAWA OSAMU
(Niigata Univ., Sch. of Med.)
TANI NAGAYUKI
(Niigata Univ., Sch. of Med.)
ITO SEIKI
(Akita Univ., Sch. of Med.)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.42;NO.3;PAGE.187-191(1999)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In order to elucidate the effect of biguanide on changes in the glomerular filtration rate(GFR) after ingestion of protein, 15 healthy volunteers were studied. The following variables were determined before and after eating cooked beef containing 0.8g protein/kg of body weight with and without metformin: GFR, concentration of plasma amino acids, serum lactate. GFR rose significantly (p<0.01) after ingestion of cooked beef. Increased GFR after ingestion of beef was suppressed by administering metformin pretreatment. The increases in plasma alanine and serum lactate after ingestion of beef with metformin pretreatment were larger (p<0.05) than after ingestion of beef alone. Thus, metformin reduces the GFR increase response after ingestion of meat. These results suggest that biguanide inhibits glomerular hyperfiltration induced by the intake of protein. (author abst.) |
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