Studies of Helicobacter pylori Eradication Treatment. Modification of Eradication Therapy to Gain a Higher Eradication Rate.
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Accession number;99A0526257
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| Title;Studies of Helicobacter pylori Eradication Treatment. Modification of Eradication Therapy to Gain a Higher Eradication Rate. |
| Author;
KAISE MITSURU
(Toshiba Byoin)
MIWA JUN
(Toshiba Byoin)
SUZUKI NOBUAKI
(Toshiba Byoin)
OTA YASUHIKO
(Toshiba Byoin)
KANAI KOICHI
(Toshiba Byoin)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.15;NO.5;PAGE.793-800(1999)
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| Figure&Table&Reference;FIG.3, TBL.3, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;One hundred and fifty-six patients with H. pylori-positive peptic ulcer were randomly assigned to the following three groups, and H. pylori eradication rate were compared. The groups comprised the OAC group, who underwent a one week-triple therapy using omeprazole at 40mg/day, amoxicillin at 1500mg/day, and clarithromycin at 800mg/day; the oxidizing water-lavage group, who underwent a concomitant therapy with the triple therapy and endoscopy-guided gastric lavage with oxidizing water on the first day; and the pronase group, who underwent a concomitant therapy with the triple therapy and pronase at 54000units/day, which is a solvent of the gastric mucus, a possible sanctuary of H. pylori. One hundred and sixty-two patients were added to the OAC group for further studies to demonstrate eradication rate, incidence of adverse events, and causality of bacterial eradication failure in a large number of patients. H. pylori eradication rates obtained by ITT analysis were 90.4%(47/51) for the OAC group, 92.0%(46/50) for the oxidizing water-lavage group, and 90.6%(48/53) for the pronase group, showing no significant differences among the three groups. Incidence of adverse events tended to be higher in the oxidizing water-lavage group than in the pronase group(p=0.077). In the OAC group, H. pylori eradication rate was high at 91.0%(193/212), with no serious adverse events, although incidence of minor adverse events including loose stool and abnormal sense of taste was 32.8%. These results were similar to those previously reported. Comparison of eradication rates by etiologic factor revealed that eradication rate from patients with duodenal ulcer tended to be higher than those with gastric ulcer. There were no differences associated with external factors as smoking or other medications.... (author abst.) |
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