Renoprotective effects of a hot water extract of Agaricus blazei fruiting bodies in experimental renal injury assessed by a DOCA-NaCl hemi-nephrectomized rats.
|
Accession number;99A0536483
|
| Title;Renoprotective effects of a hot water extract of Agaricus blazei fruiting bodies in experimental renal injury assessed by a DOCA-NaCl hemi-nephrectomized rats. |
| Author;
EGUCHI FUMIO
(Tokyo Univ. of Agric.)
WATANABE YASUO
(Tokyo Medical College)
KIKUKAWA TADAHIRO
(St. Marianna Univ.)
YOSHIMOTO HIROAKI
(Nihombaio)
ABE CHIYUKI
(St. Marianna Univ.)
HIGAKI MIYATO
(Tokyo Univ. of Agric.)
|
Journal Title;Journal of Traditional Medicines
|
Journal Code:Y0941A
|
ISSN:1340-6302
|
|
VOL.16;NO.1;PAGE.24-31(1999)
|
| Figure&Table&Reference;FIG.5, TBL.4, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Renoprotective effects of Agaricus blazei fruit hot water extract(CJ-01) on the incidence and severity of renal dysfunctions in the deoxycorticosterone acetate(DOCA)-salt treated with the heminephrectomized rats were investigated. CJ-01(10g/600ml) was extracted 80.DEG.C. for 1hr and a dose of 10g/60kg/day was taken, freely. Experimental animals(32 male Wistar rats) were divided into the following five groups; I. sham-operation with 1% NaCl, II. sham-operation with CJ-01(for 90 days) diluted in 1% NaCl, III. hemi-nephrectomy with DOCA(20mg/kg s.c., one day/week for 70 days) and 1% NaCl, IV. hemi-nephrectomy with DOCA and CJ-01(for 90 days) diluted in 1% NaCl, V. hemi-nephrectomy with DOCA and CJ-01(for 49 days during the maximum hypertension was appeared) diluted in 1% NaCl. All animals were freely drinking a 1% NaCl solution through the experimental period. After the left kidney was removed, the marked increased in volume of urine was observed in the DOCA-salt treated groups(III, IV, V). Particularly, these increases were significantly enhanced compared to I and II groups after the maximum hypertension was detected. However, in the CJ-01 treated groups(IV and V), such severe hyperurination was markedly blocked whereas the severe hypertension was not inhibited. At 90 days, the weight and size of the right-side kidney in the III group was about two folds more than those of the I and II groups, although the consecutive treatment of CJ-01 seen in the IV and V groups significantly inhibited the enlargement of right side kidney. Furthermore, the abnormal values (i.e., urine protein, cholesterol, corticosterone, etc.) detected in the urine and serum examinations of the DOCA-NaCl and hemi-nephrectomized group were significantly improved by the treatment of CJ-01. The pathological evidences also elucidated the significant uroprotecive effects of CJ-01 on the severe kidney diseases.... (author abst.) |
|
|
|
Related Articles;
|
|
