The effects of chlormadinone acetate on the prostate of rats treated with adrenal androgens.
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Accession number;99A0636504
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| Title;The effects of chlormadinone acetate on the prostate of rats treated with adrenal androgens. |
| Author;
GOTANDA KOTARO
(Teikoku Horm. Mfg. Co., Ltd.)
SHIMBO ATSUSHI
(Teikoku Horm. Mfg. Co., Ltd.)
NAKANO YOICHI
(Teikoku Horm. Mfg. Co., Ltd.)
SASAKI TAKAKO
(Teikoku Horm. Mfg. Co., Ltd.)
HONMA SEIJIRO
(Teikoku Horm. Mfg. Co., Ltd.)
MIYASAKA KATSUHIKO
(Teikoku Horm. Mfg. Co., Ltd.)
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Journal Title;Medical Consultation & New Remedies
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Journal Code:Z0942A
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ISSN:0037-380X
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VOL.36;NO.4;PAGE.277-283(1999)
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| Figure&Table&Reference;FIG.2, TBL.5, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;For the endocrine therapy of prostate cancer, antiandrogen is generally used by the combination with surgical or medical castration, namely as combined androgen blockade. It is well known that some adrenal androgens are converted into testosterone(T) and dihydrotestosterone(DHT) which are more powerful androgens than the adrenal androgens. Role of antiandrogen in combined androgen blockade is thought to block the action of androgens derived from adrenal in the prostate. First, we evaluated the antiandrogenic actions of chlormadinone acetate(CMA), allylestrenol, flutamide, hydroxyflutamide, and bicalutamide by binding assay with androgen receptors. Among these antiandrogens, CMA inhibited most potently binding of radio labeled ligand to androgen receptors. Secondly, we evaluated the effects of CMA(3,5, and 10mg/kg p.o., twice daily for 14 days) on the prostate weight, plasma concentrations of T and dehydroepiandrosterone(DHEA), and DHT content of the prostate in castrated rats receiving T or DHEA. CMA suppressed dose-dependently prostate weight gain induced both by exogenous T and by exogenous DHEA. CMA did not influence plasma and prostate level of androgens measured in the present study. We concluded that CMA inhibited the activity of the adrenal androgen, and that its effect was due to blocking effect on the interaction of DHT with androgen receptors. (author abst.) |
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