Membrane-Type Matrix Metalloproteinases in Tumor Invasion and Metastasis.
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Accession number;99A0415040
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| Title;Membrane-Type Matrix Metalloproteinases in Tumor Invasion and Metastasis. |
| Author;
SEIKI MOTOHARU
(Inst. of Med. Sci., Univ. of Tokyo)
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Journal Title;Nishinihon Journal of Urology
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Journal Code:Z0253B
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ISSN:0029-0726
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VOL.61;NO.3;PAGE.200-205(1999)
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| Figure&Table&Reference;FIG.4, REF.31 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Matrix metalloproteinases(MMPs) regulate formation and remodeling of tissue by degrading extracellular matrix(ECM). At least 18 MMPs(MMP family) have been identified and the number is still increasing. Four of them are membrane-type MMPs(MT-MMPs) that have a transmembrane domain and a short cytoplasmic tail. Although MT4-MMP has not been identified yet, recombinant MT1-, MT2- and MT3-MMP show activity against some ECM components and also induce specific activation of pro-gelatinase A which has been reported to be activated uniguely by a cell surface activator. Compared to the soluble-type MMPs, cell surface MMPs are responsible for limited ECM degradation at the periphery of cells, which is thought to be important for regulation of the functions of cells in tissue, such as proliferation, apoptosis, morphogenesis, motility and invasion etc. Aberrant expression of MT1-MMP is frequently associated with various types of malignant tumors and is correlated with the activation of gelatinase A in the tissue and with tumor spread. Enforced expression of MT1-MMP in tumor cell lines increases the invasive and metastatic potential of the cells. Thus, MT1-MMP is thought to be a key molecule for tumor cell invasion and a target molecule to treat invasive tumors. (author abst.) |
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