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Accession number;99A0515708
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| Title;Effect of Troglitazone on the Function of Human Mesangial Cells Cultured with High Glucose Media. |
| Author;
TADA HISAYA
(Toho Univ., Sch. of Med.)
NOMURA KAYOKO
(Toho Univ., Sch. of Med.)
KUBOKI KOJI
(Toho Univ., Sch. of Med.)
INOKUCHI TOSHIKI
(Toho Univ., Sch. of Med.)
ISOGAI SHO
(Toho Univ., Sch. of Med.)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.42;NO.4;PAGE.275-279(1999)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We investigated the effects of troglitazone (Tr) on the proliferation and synthesis of transforming growth factor-.BETA. (TGF-.BETA.) and fibronectin in human mesangial cells (MC) cultured with either low or high levels of glucose. Treatment of MC with Tr caused a decrease in both DNA content and [3H]-thymidine uptake in the cells cultured with concentrations of 5mM and 33mM glucose. Incubation of MC with 33mM glucose resulted in an increase in the production of TGF-.BETA. and fibronectin compared with 5mM glucose. However, the high glucose-induced increase in TGF-.BETA. and fibronectin was halted by Tr. Accordingly, the effects of Tr on these MC functions may justify its clinical trial for treatment of diabetic nephropathy. (author abst.) |
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