Clinical Characteristics of Slowly Progressing IDDM in Childhood at the Time of Diagnosis.
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Accession number;99A0515709
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| Title;Clinical Characteristics of Slowly Progressing IDDM in Childhood at the Time of Diagnosis. |
| Author;
URAKAMI TATSUHIKO
(Nihon Univ., Surugadai Hosp.)
MATSUNAGA HIROKO
(Nihon Univ., Surugadai Hosp.)
MIYAMOTO YUKINOBU
(Nihon Univ., Surugadai Hosp.)
FUJITA HIDEHIRO
(Nihon Univ., Surugadai Hosp.)
OWADA MISAO
(Nihon Univ., Surugadai Hosp.)
KITAGAWA TERUO
(Tokyo Health Serv. Assoc.)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.42;NO.4;PAGE.281-288(1999)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.24 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We investigated the clinical characteristics at the time of diagnosis of slowly progressing IDDM in 44 children that was detected by chance through urine glucose screening at school. (1) Female predominance (66%) was distinct. In the majority of cases, onset was in adolescence. (2) The average BMI was 17.0.+-.1.7kg/M2, and no case of obesity was found. (3) A family history of NIDDM (36%) among their first-degree relatives was found. (4) Deterioration in pancreatic .BETA.-cell function and metabolic disorder were milder than in abrupt onset IDDM. (5) The incidence of antibodies against pancreatic .BETA.-cells was approximately 60% with low antibody titers. (7) Associations of DR 4, DQB 1*0401 (susceptible) and DR 2, DQB 1*0602 (protective) were not significant in contrast to abrupt onset IDDM. These findings indicate the heterogeneity in the clinical course of IDDM, and the possibility of two different subtypes in Japanese children, i.e. acute and slow clinical forms. (author abst.) |
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