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Accession number;99A0620762
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| Title;A Case of Insulin-Dependent Diabetes Mellitus in the Aged. |
| Author;
KIMURA FUMIAKI
(Daijukai Daijukaibyoin)
FUKUI MICHIAKI
(Daijukai Daijukaibyoin)
SAWADA MANABU
(Daijukai Daijukaibyoin)
FUJII MITSUHIRO
(Daijukai Daijukaibyoin)
KITANO MORIHISA
(Daijukai Daijukaibyoin)
OBAYASHI HIROSHI
(Kyoto Biseibutsu Kenkyusho)
SHIGETA HIROFUMI
(Kyoto Prefect. Univ. of Med.)
NAKAMURA NAOTO
(Kyoto Prefect. Univ. of Med.)
KONDO MOTOHARU
(Kyoto Prefect. Univ. of Med.)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.42;NO.5;PAGE.347-351(1999)
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| Figure&Table&Reference;FIG.2, TBL.3, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We describe our experience with a case of insulin-dependent diabetes mellitus(IDDM) with sudden onset in a 78-year-old woman. The diagnosis of IDDM was made because she abruptly developed severe hyperglycemia with ketosis due to exhausted endogenous insulin release. The patient showed antibodies to glutamic acid decarboxylase(GAD) detected by radioimmunoassay and Western blotting. However, this finding was contrary to previous reports in the literature, which assert that the antibodies to GAD in IDDM patients are generally recognized conformational epitopes of GAD. In addition, this patient showed no characteristic IDDM human leukocyte antigen(HLA) such as DR4 and DR9. These immunological and genetical differences may be key factors in the aged in developing IDDM. (author abst.) |
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