Effect of Single and Divided Ingestions of the Nondigestible Oligosaccharide "Galactosylsucrose" on Transitory Diarrhea and Laxative Threshold in Normal Female Subjects.
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Accession number;99A0772727
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| Title;Effect of Single and Divided Ingestions of the Nondigestible Oligosaccharide "Galactosylsucrose" on Transitory Diarrhea and Laxative Threshold in Normal Female Subjects. |
| Author;
OKU TSUNEYUKI
(Kenritsunagasakishiborutodai)
OKAZAKI MITSUKO
(Kagawa Nutr. Jr. Coll.)
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Journal Title;Journal of Japanese Society of Nutrition and Food Science
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Journal Code:F0624A
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ISSN:0287-3516
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VOL.52;NO.4;PAGE.201-207(1999)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In order to investigate the effects of ingestion frequency of the nondigestible oligosaccharide galactosylsucrose on transitory diarrhea, a standard daily amount was divided into one, two or three parts, which were then ingested separately by 17 normal female subjects once, twice or three times in a day. Single ingestion of 60 g and 45 g of galactosylsucrose caused diarrhea in 9 of 14 subjects (64.2 %) and 3 of 8 subjects (37.5 %), respectively. However, when taken in two or three divided doses in a day, no diarrhea occurred in any of the subjects, even though the total amount ingested in one day was the same (60 g or 45 g). Furthermore, three divided ingestions of 30 g galactosylsucrose (total 90 g/day) did not cause diarrhea in 3 of 5 subjects. These results demonstrate that when the same amount of nondigestible oligosaccharide ingested in a day is divided into two or more parts and ingested separately, the level per day inducing transitory diarrhea becomes markedly higher than the laxative threshold estimated using a single ingestion of the test substance. In addition, the laxative threshold of galactosylsucrose was found to be 0.802 g/kg body weight, which is greatly higher than that of other nondigestible oligosaccharides. (author abst.) |
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