The effects of hyaluronan and periosteal grafting for articular cartilage defects in rabbit knees-An pathological and biochemical study.
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Accession number;99A0686166
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| Title;The effects of hyaluronan and periosteal grafting for articular cartilage defects in rabbit knees-An pathological and biochemical study. |
| Author;
KATSUMI AKIRA
(Chiba Univ.)
HARADA YOSHITADA
(Chiba Univ.)
WADA YUICHI
(Chiba Univ.)
ISHIMA MASAHIRO
(Chiba Univ.)
SASHO TAKAHISA
(Chiba Univ.)
NAKAGAWA KOICHI
(Chiba Univ.)
MORIYA HIDESHIGE
(Chiba Univ.)
MIYAUCHI SATOSHI
(Seikagaku Kogyo Co., Ltd.)
MIZUNO SHOJI
(Seikagaku Kogyo Co., Ltd.)
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Journal Title;Clinical Rheumatology and Related Research
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Journal Code:L0625A
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ISSN:0914-8760
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VOL.11;NO.2;PAGE.128-134(1999)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effects of hyaluronan on periosteal grafts for large osteochondral defects were studied in rabbit knees. Large osteochondral defects were created in the anterior side of the femur of both knee joints. The periosteal grafts were harvested from the medial proximal tibia, and sutured onto the defects. A HA injection was performed in the right knee and the same volume of saline was injected as a control in the left knee. The animals were sacrificed at 1, 2, 5, 8, 12 & 24 weeks after the operation. Macroscopic, histological and biochemical findings were evaluated. For histological analysis, we used a semiquantitative histological grading system. The total histological scores of the HA group tended to be better than the control group during the 24 weeks, and especially the scores for surface regularity and integration to adjacent cartilage were significantly better in the HA group than the control group at 12 weeks (P<0.05). As for the biochemical analysis, there was no significant difference between the two groups, but there was a difference from normal articular cartilage. We consider that HA might influence articular surface reconstruction. This study showed that HA might have beneficial effects on autologous periosteal grafts for the repair of large, osteochondral defects of articular cartilage. (author abst.) |
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