Radiopharmaceutical chemistry in Peking University (PKU).
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Accession number;99A1007961
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| Title;Radiopharmaceutical chemistry in Peking University (PKU). |
| Author;
WANG X Y
(Peking Univ., Peijing, Chn)
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Journal Title;Abstracts of Papers. Symposium on Radiochemistry
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Journal Code:F0139B
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ISSN:1345-2762
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VOL.43rd;NO.;PAGE.44(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;English |
| Abstract;The Department of Technical Physics, Peking University consists of two specialities: nuclear physics and applied chemistry. The applied chemistry speciality used to be radiochemistry speciality before 1983. Now its research activities cover four directions: radiopharmaceutical chemistry, material science, environmental chemistry, and radiation chemistry. The research on radiopharmaceutical chemistry began in 1983. In the first 10 years our research was focused on labeling of monoclonal antibodies (McAb) with radionuclides. Both direct and indirect (i.e. via bifunctional conjugating agents) labeling methods were studied. The labeled radionuclides we studied were 90Y, 99mTc, 111In, 111Ag, 169Yb, and 188Re. Since 1992 we extended our interest to radiopharmaceuticals used for myocardial imaging. Two types of compounds were intensively studied: boronic acid adducts of technetium trioxime (BATO) and complexes containing [99mTc.IDN.N]2+ core and [99mTc=NAr]3+ core. In the mean while, we carried out the investigations on relevant coordination chemistry of Tc in aqueous solution for increasing the knowledge of chemical behavior of Tc in vivo. As the great potential usage of 186Re and/or 188Re pharmaceuticals in cancer therapy is realized, more economic and convenient methods for their production have to be developed. We explored the possibility of preparation of 186/188Re with a satisfactorily high specific activity by Szilard-Chalmers effect from rhenium complex target irradiated with thermal neutron in a nuclear reactor. We also worked out a new procedure for separation of radioactive rhenium from tungsten target bombarded by proton beam. In the recent five years we were involved in development of drugs used for neutron capture therapy (NCT).... (author abst.) |
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