Effects of Co-administered Fluvoxamine and Diazepam, Ethyl loflazepate or Imipramine on Marble-burying Behavior in Mice.
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Accession number;99A1013021
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| Title;Effects of Co-administered Fluvoxamine and Diazepam, Ethyl loflazepate or Imipramine on Marble-burying Behavior in Mice. |
| Author;
HAYASHI AKIKO
(Meiji Seika Kaisha, Ltd.)
YAMASHITA NOBUYUKI
(Meiji Seika Kaisha, Ltd.)
BABA JUN
(Meiji Seika Kaisha, Ltd.)
ICHIMARU YASUYUKI
(Meiji Seika Kaisha, Ltd.)
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Journal Title;Pharmacometrics
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Journal Code:S0617A
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ISSN:0300-8533
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VOL.57;NO.5/6;PAGE.103-108(1999)
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| Figure&Table&Reference;FIG.5, TBL.3, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The authors studied the effects of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), which was administered alone or with benzodiazepine anxiolytics and a tricyclic antidepressant, on a marble burying behavior in mice, a model of anxiety and/or obsessive compulsive disorder (OCD). Fifteen minutes after the intraperitoneal administration of drugs, the animal was individually placed into the cubic box (30*30*30 cm) in which 25 clean glass marbles (20 mm diameter) were evenly placed at 5 cm intervals on a 5 cm layer of sawdust, and was allowed to move freely for 30 min. The number of marbles left uncovered by sawdust was counted at the end of the experiment. Spontaneous motor activity of the animal was also counted under the condition without marble and sawdust in the same apparatus as a separate experiment. The marble burying behavior in mice was suppressed by the administration of fluvoxamine (45 mg/kg), diazepam (1.0 and 3.2 mg/kg), ethyl loflazepate (3.2 mg/kg) or imipramine (10, 20 and 30 mg/kg). Then, the effects of co-administration of fluvoxamine and each of diazepam, ethyl loflazepate and imipramine were examined at the submaximal doses for suppressing the marble burying behavior when they were solely administered. Co-administration of fluvoxamine 10 mg/kg and diazepam 1.0 mg/kg or ethyl loflazepate 0.32 mg/kg potentiated their suppressive effects on the marble burying behavior without any effect on motor activity. Co-administration of fluvoxamine 10mg/kg and imipramine 10mg/kg also enhanced their suppressive effects. These results suggest that augmentation of effects occur when fluvoxamine and benzodiazepines are co-administered, and imipramine may show similar effect in co-administration with fluvoxamine in marble burying behavior in mice. (author abst.) |
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