Antihypertensive Effect of Sardine Peptide and Valyl-Tyrosine in Spontaneously Hypertensive Rats.
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Accession number;99A1022130
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| Title;Antihypertensive Effect of Sardine Peptide and Valyl-Tyrosine in Spontaneously Hypertensive Rats. |
| Author;
SEKI EIJI
(Senmi Ekisu Co., Ltd.)
KAWASAKI TERUKAZU
(Kyushu Univ., Inst. of Health Sci.)
YOSHIDA MAYUMI
(Senmi Ekisu Co., Ltd.)
OSAJIMA KATSUHIRO
(Senmi Ekisu Co., Ltd.)
TAMAYA KEI
(Kyushu Univ., Fac. of Agric.)
MATSUI TOSHIRO
(Kyushu Univ., Fac. of Agric.)
OSAJIMA YUTAKA
(School of Bioscience, Hiroshima Prefectural Univ.)
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Journal Title;Journal of Japanese Society of Nutrition and Food Science
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Journal Code:F0624A
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ISSN:0287-3516
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VOL.52;NO.5;PAGE.271-277(1999)
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| Figure&Table&Reference;FIG.4, REF.32 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The antihypertensive effect of peptides (Y-2) derived from sardine, valyl-tyrosine and -mixture (MIX) of four dipeptides having angiotensin converting enzyme inhibitory activity was studied in spontaneously hypertensive rats (SHR). 1) Single oral administration of Y-2, valyl-tyrosine and MIX lowered the systolic blood pressure in SHR, and its minimum effective doses were 10, 1, and 10 mg/kg, respectively. These effects lasted for 8 h after administration. The hypotensive potency of valyl-tyrosine was greater than those of Y-2 and MIX. Valyl-tyrosine (1 and 10 mg/kg) lowered the blood pressure dose-dependently. 2) When 1000, 10, and 10 mg of Y-2, valyl-tyrosine and MIX, respectively, were administered orally to the SHR twice a day for 10 consecutive days, any of the regimens decreased systolic blood pressure significantly, and the decrement of systolic blood pressure continued for 5 days thereafter. These results indicate that either Y-2, valyl-tyrosine or MIX can exert a potent and long-lasting antihypertensive effect in SHR. (author abst.) |
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