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Accession number;00A0163466
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| Title;Artificial DNAs with Metal Coordination Sites as Nucleobases. |
| Author;
TANAKA KENTARO
(Univ. of Tokyo, Grad. Sch.)
CAO H
(Graduate Univ. Advances Studies)
TASAKA MOTOYUKI
(Graduate Univ. Advances Studies)
SHIONOYA MITSUHIKO
(Univ. of Tokyo, Grad. Sch.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.14th;NO.;PAGE.12-13(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We have recently reported the metal-assisted base pairing formed by artificial .BETA.-C-nucleosides having a phenylenediamine moiety as the metal chelating site. In this base pair, hydrogen bonding is replaced by metal coordination, thereby creating a novel binding motif in duplex DNA (Chart 1). This paper describes convenient syntheses of the other two types of artificial .BETA.-C-nucleosides possessing a metal chelating site (2-aminophenol and catechol) as the nucleobase moiety to control the net charges of metal-assisted base pairs (Figures 1 and 2). These nucleosides were synthesized via Friedel-Crafts coupling reactions as the key step between the aromatic ring and ribose moieties, whereas the nucleoside having a phenylenediamine moiety was prepared in rather longer steps through an RNA type intermediate followed by the removal of 2'-hydroxy group. (author abst.) |
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