Photo-regulation of the RNA Hydrolysis by Zinc(II) Complexes Carrying Azobenzene.
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Accession number;00A0163473
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| Title;Photo-regulation of the RNA Hydrolysis by Zinc(II) Complexes Carrying Azobenzene. |
| Author;
KAWATA KENTARO
(Univ. of Tokyo, Grad. Sch.)
SUMAOKA JUN
(Univ. of Tokyo, Grad. Sch.)
KOMIYAMA MAKOTO
(Univ. of Tokyo, Grad. Sch.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.14th;NO.;PAGE.26-27(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Non-enzymatic hydrolysis of RNA is potent for a variety of applications, and a number of active catalysts have been already reported. However little has been known yet on the control of catalytic activity. Thus we have designed a new zinc(II) complex of a dinucleating ligand L1 which carries a photo-responsive azobenzene in the linker. The 1:2 L1-Zn complex, generated in situ by adding stoichiometric amounts of L1 and Zn(NO3)2 to an aqueous buffer solution, effectively hydrolyzed ApA. The pseudo-first-order rate constant was 0.35h-1. When the solution was irradiated with UV light (300nm<.LAMBDA.<400nm), the hydrolysis rate notably decreased (the rate constant was 0.11h-1). When the mixture was further irradiated with visible light (.LAMBDA.>420nm), the catalytic activity was restored and the rate constant was increased to 0.31h-1. In conclusion, the rate of RNA hydrolysis has been reversibly photo-controlled by using the Zn(II) complexes carrying an azobenzene residue in the ligand. (author abst.) |
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