Modification of Immunofunction by .ALPHA.-1,3-Glucan.
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Accession number;00A0163477
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| Title;Modification of Immunofunction by .ALPHA.-1,3-Glucan. |
| Author;
YAMAGUCHI TATSUAKI
(Chiba Inst. of Technol.)
HONDA MIHO
(Chiba Inst. of Technol.)
TAKIGUCHI YASUYUKI
(Chiba Inst. of Technol.)
WADA MASAHIRO
(Tokyo Univ. of Agric.)
FUNADA URARA
(Tokyo Univ. of Agric.)
MUKASA HIDEHIKO
(Natl. Def. Med. Coll.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.14th;NO.;PAGE.34-35(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Immunological enhancement of .BETA.-1,3-glucan in Basidiomycetes and arabinoxylan in rice straw has been widely investigated. However, immunofunction of .ALPHA.-1,3-glucan were studied slightly. A large-scale production of .ALPHA.-1,3-glucan was achieved by E. coli encoding a glucosyltransferase from Streptcoccus sobrinus. In this work, immunofunction of .ALPHA.-1,3-glucan were examinned by using mice. 6-week-old BALB/c mice were fed with the diets containing 5% of .ALPHA.-1,3-glucan, arabinoxylan, or cellulose for 35 days. The lympocytes were stained with labelled antibodies, and the contents of CD4, CD8, and NK cells were analyzed by flowcytmetry. The cell numbers of CD4 and NK of mice fed with .ALPHA.-1,3-glucan and arabinoxylan were statistically higher than those fed with cellulose. These data are to be expected to use .ALPHA.-1,3-glucan as a new immunomodulator. (author abst.) |
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