Structure, Function, and Novel Enzyme Inhibitors of Vertebrate Squalene Epoxidase.
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Accession number;00A0163478
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| Title;Structure, Function, and Novel Enzyme Inhibitors of Vertebrate Squalene Epoxidase. |
| Author;
ABE IKURO
(Univ. of Shizuoka, Sch. of Pharm. Sci.)
SEKI TAKAHIRO
(Univ. of Shizuoka, Sch. of Pharm. Sci.)
KASHIWAGI KENJI
(Univ. of Shizuoka, Sch. of Pharm. Sci.)
NOGUCHI HIROSHI
(Univ. of Shizuoka, Sch. of Pharm. Sci.)
SAKAKIBARA JUN
(Niigata Univ., Sch. of Med.)
ONO TERUO
(Niigata Univ., Sch. of Med.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.14th;NO.;PAGE.36-37(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Squalene epoxidase(SE) is a non-P450 flavoprotein monooxygenase the catalyze the conversion of squalene to (3S)2,3-oxidosqualene. We report herein, (1) structure and bacterial expression of human SE, (2) enzyme inhibition by natural and synthetic galloy esters, and (3) molecular modeling studies based on the crystal structure of bacterial p-hydroxy-benzoate hydroxylase. (author abst.) |
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