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Accession number;00A0163505
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| Title;Molecular Recognition Behavior Specific to Functionalized Macrocyclic Sugar Clusters in Aqueous Media. |
| Author;
HAYASHIDA OSAMU
(Kyushu Univ.)
KATO MASAKI
(Kyushu Univ.)
AKAGI KAZUYUKI
(Kyushu Univ.)
AOYAMA YASUHIRO
(Kyushu Univ.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.14th;NO.;PAGE.94-95(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;31P NMR, dynamic light scattering, and transmission electron microscopy studies indicate that Na2HPO4 is bound (K>>3*103M-1) strongly to macrocyclic sugar clusters G2 or G5 via hydrogen bonding in water, the macrocyclic cluster hosts being thereby aggregated or even agglutinated in case of G5 to form precipitates. The efficiencies of these interactions, in terms of % effective protonation (-20% with G2 and -90% with G5) of HPO42- and the rates of agglutination (inminutes for G5 and days for G2), are highly dependent on the oligosaccharide chain-lengths. The agglutination of long-chain host G5 can be induced by other simple salts having a multivalent anion such as Na2SO4. Nucleotides are also good guests of hosts G2 and G5. The significance of clustering oligosaccharide chains is duscussed in light of the important roles of biological oligosaccharides on the cell surfaces. (author abst.) |
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