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Accession number;99A0970383
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| Title;A novel anti-inflammatory substance : Effects of Agaricus blazei murri (CJ-01) on spontaneous arthritis in MRL/1pr mice and tyipe II collagen-iuduced arthritis in DBA/1J mice. |
| Author;
KIKUKAWA TADAHIRO
(St. Marianna Univ.)
EGUCHI FUMIO
(Tokyo Univ. of Agric.)
ABE CHIYUKI
(St. Marianna Univ.)
YOSHIMOTO HIROAKI
(Nihombaio)
HIGAKI MIYATO
(Tokyo Univ. of Agric.)
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Journal Title;Japanese Journal of Inflammation
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Journal Code:Y0899A
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ISSN:0389-4290
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VOL.19;NO.5;PAGE.261-267(1999)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effect of Agaricus blazei Murri (CJ-01)was studied in animal experimental models for arthritis to evaluate its efficacy. Spontaneous polyarthritis in MRL/Mp-1pr/1pr(MRP/1pr)mice and type II collagen-induced arthritis(CIA) in DBA/1J mice were studied. CJ-01 significantly reduced the incidence and severity of paw swelling in CIA in DBA/1J mice. And suppressed in serum C-reactive protein, lactate dehydrogenase and IgG-type rheumatoid factor levels in MRL/1pr mice. A high level of serum anti-type II collagen antibody was also suppressed in the group treated with dexamethasone but not CJ-01. Histopathological examination showed that CJ-01 proliferative inflammatory articular lesions were suppressed and a bone-remodelling effect was observed under a microscope. The bone-remodelling effect indicates both suppression of absorption and new bone formation. These results suggest that CJ-01 has and anti-arthritic effect and may be avaluable therapeutic drug for inflammatory disease. (author abst.) |
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