PEBP2/CBF/AML1: Master Regulators for Tissue Specific Gene Expression.
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Accession number;00A0108453
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| Title;PEBP2/CBF/AML1: Master Regulators for Tissue Specific Gene Expression. |
| Author;
ITO YOSHIAKI
(Inst. for Virus Res., Kyoto Univ.)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.45;NO.1;PAGE.1-6(2000)
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| Figure&Table&Reference;FIG.1, REF.25 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;This paper explains first how the discovery of PEBP2 has been done, and the knowledge about its molecular structure. Its important roles and the future research targets are explained next. PEBP2 is consisted of 2 subunits of .ALPHA. and .BETA., and acts as a transcription factor deeply involved in development and differentiation of animals. Mammalian PEBP2.BETA. is composed of 3 types of Runx1, 2 and 3 genes as Runt domain-related genes of Drosophila, but PEBP2.ALPHA. has been found only one type. Adult-type hemopoietic stem cells are not formed in the mice knocked out Runx1 gene. In the knockout-mice without Runx2 gene, ossification is not occured. These genes are explained to act as master genes. PEBP2s are bound to Smad signal transduction molecules after being activated by TGF-.BETA./BMP by binding to its receptors, and the researches are now done on their actions as molecular switches, the cause of haploinsufficiency, enhansosome formation, and carcinogenetic actions. |
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