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Accession number;00A0108457
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| Title;PEBP2/CBF/AML1: Master Regulators for Tissue Specific Gene Expression. Mechanism of Leukemogenesis Induced by AML 1-MTG 8. |
| Author;
KITABAYASHI ISSEI
(National Cancer Center Res. Inst.)
OKI MISAO
(National Cancer Center Res. Inst.)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.45;NO.1;PAGE.26-32(2000)
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| Figure&Table&Reference;FIG.10, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;As a result of human autosomal translocation of t(8;21), AML 1 gene is fused to MTG 8 gene, and AML 1-MTG 8 fusion protein is expressed. Authors analyze human luekomogenesis of acute myelocytic leukemia by this fusion protein by in vitro experiments using L-G cell line established from mouse IL-3 dependent myeloid cells. AML 1 transcription factor promotes the cytodifferentiation from myeloblasts to neutrophils by forming its complex of histone acetylation enzyme including p300/CBP. AML 1-MTG 8 inhibits cytodifferentiation to neutrophils by suppressing the action of AML 1 by forming the complex of histone deacetylation enzyme mediated through MTGR 1/MTG 16. The inhibition of cytodifferentiation is found to be recovered by trichostatin A by inhibiting the action of AML 1-MTG 8. |
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