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Accession number;00A0108458
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| Title;PEBP2/CBF/AML1: Master Regulators for Tissue Specific Gene Expression. Leukemogenesis by the AML1/EVI-1 Chimeric Protein. |
| Author;
MITANI KINUKO
(Univ. of Tokyo, Fac. of Med.)
HIRAI HISAMARU
(Univ. of Tokyo, Fac. of Med.)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.45;NO.1;PAGE.33-39(2000)
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| Figure&Table&Reference;FIG.5, REF.31 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;AML1/EVI-1 chimeric gene was cloned from cDNA library of SKH1 cell line established from a patient with acute crisis of megakaryoblasts of chronic myelogenous leukemia. It was formed as a result of autosomal translocation of t(3;21). It seems to be involved in the progression of hemopoietic stem cell cancer. This paper explains the following items:1) AML1/EVI-1 structure, 2) inhibitory function of cytodifferentiation in Runt homologous domain of AML1, 3) proliferation-stimulative function in the second zinc finger domain of EVI-1, and 4) functions of both proliferation inhibition failure and apoptosis suppression in the first zinc finger domain of EVI-1. |
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