Science Links Japan | PEBP2/CBF/AML1: Master Regulators for Tissue Specific Gene Expression. Molecular Mechanisms of PEBP2/CBF as a Master Regulator of Tissue-specific Gene Expression.

PEBP2/CBF/AML1: Master Regulators for Tissue Specific Gene Expression. Molecular Mechanisms of PEBP2/CBF as a Master Regulator of Tissue-specific Gene Expression.

Accession number;00A0108461

Title;PEBP2/CBF/AML1: Master Regulators for Tissue Specific Gene Expression. Molecular Mechanisms of PEBP2/CBF as a Master Regulator of Tissue-specific Gene Expression.

Author; SHIGESADA KATSUYA (Inst. for Virus Res., Kyoto Univ.)

Journal Title;Protein, Nucleic Acid and Enzyme

Journal Code:F0325A

ISSN:0039-9450

VOL.45;NO.1;PAGE.55-62(2000)

Figure&Table&Reference;FIG.4, REF.14

Pub. Country;Japan

Language;Japanese

Abstract;This paper introduces recent knowledges on the molecular structure and the functional characteristics of PEBP2 especially as a tissue-specific transcription factor. PEBP2/CBF is a hetero-dimer composed of .ALPHA. subunit which binds to DNA and of .BETA. subunit which binds to non-DNA molecule. The space structures of Runt domain in .ALPHA. subunit and of .BETA. subunit have recently been determined by NMR analyses. It is proven that Runt domain has the structure of S type immunoglobulin folding composed of .BETA. sheet structure as a frame, and .ALPHA. subunit is composed of many functional modules which are complicatedly influencing each other.

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