Effect of Sepimostat mesilate(FUT-187) on Reflux Esophagitis after Gastrectomy in Rats.
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Accession number;00A0193259
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| Title;Effect of Sepimostat mesilate(FUT-187) on Reflux Esophagitis after Gastrectomy in Rats. |
| Author;
KUNISHIMA CHIYOKO
(Torii & Co., Ltd., Res. Lab.)
IKEDA ATSUSHI
(Torii & Co., Ltd., Res. Lab.)
TSURUHA JUN'ICHIRO
(Torii & Co., Ltd., Res. Lab.)
KOSHIYAMA YOSHIKO
(Torii & Co., Ltd., Res. Lab.)
ODA MINORU
(Torii & Co., Ltd., Res. Lab.)
SASAKI NOBUYUKI
(Torii & Co., Ltd., Res. Lab.)
KURUMI MASATERU
(Torii & Co., Ltd., Res. Lab.)
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Journal Title;Pharmacometrics
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Journal Code:S0617A
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ISSN:0300-8533
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VOL.58;NO.1;PAGE.17-22(1999)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The reflux esophagitis after gastric surgery is attributed to excessive exposure of the esophageal mucosa to refluxed bile and pancreatic juice from duodenum. There are clinical observations and experimental evidence to suggest that the reflux of duodenal contents into the esophagus develop Barrett columnar metaplasia and/or esophageal cancer. Sepimostat mesilate(FUT-187) has the inhibitory effects on various proteases, especially trypsin. This study was designed to determine the effect of oral administration of FUT-187 on the reflux esophagitis after gastrectomy in two different experimental models. In the first experiment, three operative procedures were performed in rats, 1) total gastrectomy and Billroth-II reconstruction, 2) total gastrectomy and Roux-Y reconstruction, 3) partial gastrectomy and Billroth-II roconstruction. In this study, the most severe mucosal ulceration occurred to all of rats underwent total gastrectomy with Billroth-II reconstruction at the 14th day after surgery. None of the others models showed esophageal ulcer. Therefore, total gastrectomy with Billroth-II reconstruction was chosen as the experimental model for reflux esophagitis in the present study. In this model, the area of esophageal ulcer at 14th day after oral administration of FUT-187 for 12 days and trypsin activity of juice in duodenum at 10th day after single administration of FUT-187 were determined. FUT-187 exhibited inhibitory effect on the development of esophagitis and the duodenal trypsin activity in a dose dependent manner. In the second experiment, acute reflux of duodenal contents into the esophagus was induced by keeping polyethylene tube in stomach of rats to cause acute esophageal mucosal injuries. This acute model had a mild mucosal alterations in comparison with the gastrectomized model and similarity clinical cases....(author abst.) (author abst.) |
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