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Accession number;00A0204816
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| Title;Changes in Isolated Ciliary Muscle Caused by Repeated Instillation of Carbachol Ointment in Rabbits and Effect of Topically Applied Amlexanox. |
| Author;
WATANABE NORIKO
(Senju Pharm. Co., Ltd.)
OGAWA TAKAHIRO
(Senju Pharm. Co., Ltd.)
ISAKA MITSUYOSHI
(Senju Pharm. Co., Ltd.)
YOROZUYA TOSHIYUKI
(Fac. of Pharm. Sci., Kanazawa Univ.)
USHIJIMA HIROMI
(Fac. of Pharm. Sci., Kanazawa Univ.)
GOMI YASUO
(Fac. of Pharm. Sci., Kanazawa Univ.)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.104;NO.1;PAGE.17-23(2000)
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| Figure&Table&Reference;FIG.9, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: We investigated changes in ciliary muscle caused by continual contraction in rabbits and evaluated the efficacy of topically applied amlexanox, which relaxes the ciliary muscle, on such changes. Subjects and Methods: After topical application of carbachol ointment 5 times daily for 2 weeks, the contractile responses of isolated ciliary muscles to carbachol were measured isometrically, and the ciliary smooth muscle fibers were stained with phosphotungstic acid and hematoxylin and observed histologically. 1% amlexanox solution was instilled 5 minutes before every instillation of carbachol ointment. Results: Repeated topical carbachol ointment caused decreases in both contractile responses of isolated ciliary muscles to carbachol and number of ciliary smooth muscle fibers stained by phosphotungstic acid and hematoxylin. Amlexanox inhibited these changes. Conclusion: We found that continual contraction of the ciliary muscle caused functional and histological changes in it. These changes are thought to occur in some diseases which cause excessive contraction of the ciliary muscle. Topical amlexanox might be useful for these diseases. (author abst.) |
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