Long-term Effect of Topically Applied Isopropyl Unoprostone on Microcirculation in the Choroid-retina.
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Accession number;00A0204820
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| Title;Long-term Effect of Topically Applied Isopropyl Unoprostone on Microcirculation in the Choroid-retina. |
| Author;
MAKIMOTO YUKIKO
(Osaka Medical. Coll., JPN)
SUGIYAMA TETSUYA
(Osaka Medical. Coll., JPN)
KOJIMA SHOTA
(Osaka Medical. Coll., JPN)
AZUMA IKUO
(Osaka Medical. Coll., JPN)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.104;NO.1;PAGE.39-43(2000)
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| Figure&Table&Reference;TBL.3, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To study the long-term effect of topically applied 0.12% isopropyl unoprostone(unoprostone, Rescula) on microcirculation in the ocular fundus. Materials and Methods: Using a laser speckle tissue circulation analyzer, normalized blur(NB), a quantitative index of blood flow velocity and tissue blood flow, was measured in the optic nerve head(ONH) and choroid-retina before and 4.5 hours after an instillation of placebo into both eyes in 11 normal human volunteers. Intraocular pressure(IOP), blood pressure, and pulse rate were also measured. A drop of unoprostone or the placebo was instilled into each eye in a double-blind manner twice a day for 21 days(the treated or untreated eye). Results: Twenty-one days later, NB values in the ONH and the choroid-retina increased significantly and the IOP decreased significantly only in the treated eyes. Ocular perfusion pressure showed no significant changes. Conclusions: These results suggest that the increase of the blood flow in the microcirculation in the human ocular fundus following the relatively long-term topical application of unoprostone may be due to reduction in vascular resistance. (author abst.) |
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