Vancomycin-resistant Staphylococcus aureus.
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Accession number;00A0221179
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| Title;Vancomycin-resistant Staphylococcus aureus. |
| Author;
ITO TERUYO
(Juntendo Univ., Sch. of Med.)
HANAKI HIDEAKI
(Juntendo Univ., Sch. of Med.)
HIRAMATSU KEIICHI
(Juntendo Univ., Sch. of Med.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.1;PAGE.7-23(2000)
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| Figure&Table&Reference;FIG.12, TBL.1, REF.92 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Recent emergence of vancomycin resistance in methicillin-resistant Staphylococcus aureus(VRSA) has posed a new threat to hospital infection control and antibiotic chemotherapy. The first vancomycin-resistant Staphylococcus aureus strain, Mu 50, was isolated in 1996. The level of resistance in VRSA, as judged by minimal-growth inhibitory concentration (8.MU.g/mL), is low compared to that of vancomycin-resistant enterococci(VRE). Hetero-VRSA strains exhibit vancomycin MIC levels equal to or less than 4.MU.g/mL, but, they show a heterogeneous type of resistance to vancomycin. Exposure of hetero-VRSA to concentrations of vancomycin of 4.MU.g/mL or higher reproducibly generates VRSA with a frequency of 10-6 or higher. This article provides an historical overview of the emergence of glycopeptide resistance in staphylococci and considers its mechanism of resistance. (author abst.) |
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