Experimental studies on chemotherapy with meropenem, imipenem, amikacin and sulbactam/ampicillin for sepsis in patients with hematologic diseases.
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Accession number;00A0221180
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| Title;Experimental studies on chemotherapy with meropenem, imipenem, amikacin and sulbactam/ampicillin for sepsis in patients with hematologic diseases. |
| Author;
KANAZAWA KATSUNORI
(Sumitomoseiyaku Soyakudainiken)
TOYAMA KEISUKE
(Tokyo Medical College)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.1;PAGE.24-33(2000)
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| Figure&Table&Reference;TBL.12, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To investigate in vitro antimicrobial activities and bactericidal activities of meropenem(MEPM), imipenem(IPM), amikacin(AMK) and sulbactam/ampicillin(SBT/ABPC) against 19 clinical strains isolated from the blood of septic patients with hematologic diseases, MICs at 24h and MBCs at 6h(6h-MBCs) or 24h(24h-MBCs) after the addition of antibiotics were determined. All strains tested showed relatively high susceptibility (MIC.LEQ.1.56.MU.g/mL) to some of the antimicrobials tested. Against Escherichia coli and Klebsiella pneumoniae, MEPM (MIC.LEQ.0.05.MU.g/mL), IPM (MIC.LEQ.0.39.MU.g/mL) and AMK (MIC.LEQ.6.25.MU.g/mL) showed high antimicrobial activities, but the antimicrobial activities of SBT/ABPC (12.5.LEQ.MIC.LEQ.50.MU.g/mL) were low. Although two carbapanem-resistant strains (MIC=12.5.MU.g/mL) and an AMK-resistant strain (MIC=12.5.MU.g/mL) were observed, other three strains of Pseudomonas aeruginosa tested showed relatively high susceptibilities to these antibiotics. Against Staphylococcus epidermidis, the other coagulase-negative staphylococci(CNS) and streptococci, MEPM (MIC.LEQ.1.56.MU.g/mL), IPM (MIC.LEQ.0.39.MU.g/mL) and SBT/ABPC (MIC.LEQ.3.13.MU.g/mL) showed high antimicrobial activities. Since most of the 24h-MBCs of antibiotics tested were equivalent to each MIC, it was suggested that exposure to the antibiotics at MIC for 24h showed sufficiently high bactericidal activities. On the other hand, some of the 6h-MBCs were much higher than each MIC. This result suggested that the antibiotics tested required higher concentrations than the MIC to show sufficient bactericidal activity against some isolates, in practical use. The combined effects of carbapenems and AMK or SBT/ABPC against 30 clinical strains isolated from septic patients were examined by checkerboard titration assay.... (author abst.) |
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