An autopsy case of non-Hodgkin's lymphoma complicated by fulminant infiltration by disseminated herpes zoster.
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Accession number;00A0221184
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| Title;An autopsy case of non-Hodgkin's lymphoma complicated by fulminant infiltration by disseminated herpes zoster. |
| Author;
ENDO KAZUHIRO
(Saitama Med. Sch.)
KAWAI NOBUTAKA
(Saitama Med. Sch.)
ITO KATSURO
(Saitama Med. Sch.)
TOMINAGA KAZUNORI
(Saitama Med. Sch.)
KUSUMOTO SHUYA
(Saitama Med. Sch.)
FUKUDA MASATAKA
(Saitama Med. Sch.)
MUROHASHI IKUO
(Saitama Med. Sch.)
BESSHO MASAMI
(Saitama Med. Sch.)
UNO HIROMASA
(Saitama Med. Sch.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.1;PAGE.75-78(2000)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 49-year-old woman was diagnosed with non-Hodgkin's lymphoma (IBL-like T cells) and received combination therapy consisting of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Shortly there after, she suffered a relapse and was treated with multi-agent chemotherapy, but the skin eruptions became worse and her lymph nodes were enlarged. With the patient's quality of life in mind, treatment with low-dose oral etoposide was initiated in August 1997. On July 2, 1998, herpes zoster lesions were noted in the anal region, and acyclovir, 4g/day, was administered orally for seven days. The pain diminished, but the vesicles persisted. On July 20, vesicles developed over her entire body, and generarlised herpes zoster was diagnosed. Vidarabine (600mg/day) was administered intravenously for six days, but the patient died of respiratory failure after rapid clinical deterioration. At autopsy, immunohistochemical staining with anti-varicella zoster antibody was positive for varicella-zoster virus in the lungs as well as in all other organs examined. The cause of the dissemination of the virus throughout the body was impairment of cellular immunity by the primary disease, irradiation, and chemotherapy. This emphasizes that chemotherapy should be administered to such patients with care. (author abst.) |
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