Mitomycin C Dissolved in a Reversible Thermosetting Gel. Effect on Aqueous Flare in the Rabbit Eye.
|
Accession number;00A0262553
|
| Title;Mitomycin C Dissolved in a Reversible Thermosetting Gel. Effect on Aqueous Flare in the Rabbit Eye. |
| Author;
NISHIMURA KOSAKU
(Gifu Univ., Sch. of Med.)
TANIGUCHI TOORU
(Gifu Univ., Sch. of Med.)
KAWASE KAZUHIDE
(Gifu Univ., Sch. of Med.)
SHIBAHARA SATOKO
(Gifu Univ., Sch. of Med.)
IZUMI ETSUKO
(Gifu Univ., Sch. of Med.)
KUMADA MASAKO
(Gifu Univ., Sch. of Med.)
YAMAMOTO TETSUYA
(Gifu Univ., Sch. of Med.)
KITAZAWA YOSHIAKI
(Gifu Univ., Sch. of Med.)
HOSHINA FUTOSHI
(Wakamoto Pharm. Co., Ltd.)
|
Journal Title;Journal of Japanese Ophthalmological Society
|
Journal Code:Z0666A
|
ISSN:0029-0203
|
|
VOL.104;NO.2;PAGE.82-85(2000)
|
| Figure&Table&Reference;FIG.2, TBL.1, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To determine the effects of mitomycin C (MMC) dissolved in a gel, which is as effective as a higher dose of aqueous MMC solution, on aqueous flare in rabbits. Method: We injected subconjunctivally a 0.1 ml solution of MMC containing 30, 10, 3.0, or 0.3 .MU.g of MMC dissolved in a reversible thermosetting gel in pigmented rabbits. As a control, a 0.1 ml aqueous solution of 30 .MU.g MMC was injected subconjunctivally. Aqueous flare was measured for 28 days after the injection. Results: The aqueous flare in the 30 .MU.g gel group was ato level similar to that in the 30 .MU.g aqueous solution group, but the aqueous flare in the 10, 3.0, and 0.3 .MU.g gel groups was significantly lower. The increase in the aqueous flare following the administration of MMC gel was dose-dependent. Conclusion: The administration of MMC dissolved in a gel can diminish the ocular inflammation by reducing the dose of MMC needed for the antiproliferative effect. (author abst.) |
|
|
|
Related Articles;
|
|
|
