Antioxidant Ointment Consisting of Treated Natural Materials and Very Low Concentrations of Glucocorticoid Shows Remarkable Effectiveness in Atopic Dermatitis.
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Accession number;00A0299950
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| Title;Antioxidant Ointment Consisting of Treated Natural Materials and Very Low Concentrations of Glucocorticoid Shows Remarkable Effectiveness in Atopic Dermatitis. |
| Author;
NIWA Y
(Niwa Inst. Immunology, Kochi-ken, Jpn)
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Journal Title;Pharmacometrics
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Journal Code:S0617A
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ISSN:0300-8533
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VOL.58;NO.2;PAGE.35-44(1999)
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| Figure&Table&Reference;FIG.3, TBL.3, REF.31 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We have developed an ointment, named "AOA (antioxidant analogs) ointment", consist of extract of natural plants and seeds, irradiated with far infrared ray heating, brewed with Aspergillus oryzae, and lipophilization with sesame oil, and with 0.0218% beta-methasone valerate (glucocorticoid: GC). This preparation was studied for its clinical effect in 750 patients with atopic dermatitis (AD) and its experimental effect on GC-induced skin atrophy in mice and GC-induced decrease in 3H-uptake by cultured human fibroblasts. In patients with mild or moderate AD, AOA ointment showed remarkable effects in reducing the extent and severity of involvement. Less effective was in patients with severe AD, although same effect was observed. AOA was significantly more effective in mild to moderate AD than control ointments, including an equivalent concentration of GC with or without the natural untreated extract, and the untreated extract without low dose GC. In individual patients were compared, AOA ointment was far more effective than the control GC ointment. During the tapering of the GC ointments, fifty cases of severe AD patients were applied with high concentrations of 0.12% beta-methasone valerate ointments, Out of 25 severe AD cases which were tapered by the lower GC ointments alone without AOA extract, 23 cases relapsed when 18.2% of commonly used 0.12% beta-methasone (i.e. 0.0218% beta-methasone) was applied. Among 25 severe AD patients, 19 cases did not worsen but succeeded to after tapered by 0.0218% beta-methasone valerate combined with AOA extract. In three of seven AD patients, AOA ointment improved face skin atrophy that had been induced by high concentrations of GC for more than 14years. In 551 AD patients who had applied AOA ointment continuously for 8-10years, no obvious skin atrophy was observed, In an experimental mouse model, the AOA extract in ointment reversed the decrease in skin thickness induced by high concentration of GC.... (author abst.) |
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