Induction of Phospholipid Hydroperoxides in Relation to Change of Tissue Mineral Distribution Caused by Mg Deficiency in Rats.
|
Accession number;00A0166649
|
| Title;Induction of Phospholipid Hydroperoxides in Relation to Change of Tissue Mineral Distribution Caused by Mg Deficiency in Rats. |
| Author;
CHIBA HIROSHIGE
(Tokyo Univ. Agriculture, Dep. Applied Biology and Chemistry, JPN)
FUJII AYAKO
(Tokyo Univ. Agriculture, Dep. Applied Biology and Chemistry, JPN)
MATSUZAKI HIROSHI
(Tokyo Univ. Agriculture, Dep. Applied Biology and Chemistry, JPN)
MASUYAMA RITSUKO
(Tokyo Univ. Agriculture, Dep. Applied Biology and Chemistry, JPN)
UEHARA MARIKO
(Tokyo Univ. Agriculture, Dep. Applied Biology and Chemistry, JPN)
SUZUKI KAZUHARU
(Tokyo Univ. Agriculture, Dep. Applied Biology and Chemistry, JPN)
|
Journal Title;Journal of Japanese Society of Nutrition and Food Science
|
Journal Code:F0624A
|
ISSN:0287-3516
|
|
VOL.52;NO.6;PAGE.373-380(1999)
|
| Figure&Table&Reference;TBL.10, REF.48 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The aim of the present study was to determine the effect of a magnesium(Mg)-deficient diet on phosphatidylcholine hydroperoxide(PCOOH) and phosphatidylethanolamine hydroperoxide(PEOOH) levels in relation to changes in tissue mineral distribution in rats. Weanling (3-week-old) male Wistar rats were divided into two groups: a normal diet(N) group (0.05% Mg) and a Mg-deficient diet(D) group (0.006% Mg). The D group showed an increased PCOOH level and iron content in the liver and heart compared with the N group. The D group showed a higher PCOOH level and copper content in the plasma and erythrocyte membrane than the N group. Either superoxide dismutase(SOD) or glutathione peroxidase(GPX) activity was decreased in the liver, heart, kidney and plasma of the D group. The level of urinary 8-hydroxydeoxyguanosine(8-OHdG), a marker of oxidative DNA damage, was 2-fold higher in the D group than in the N group. The increase in the urinary 8-OHdG level suggested oxidative DNA damage to tissues. It is concluded that a change of iron or copper induces phospholipid hydroperoxidation by increasing of PCOOH or PEOOH in the liver, heart, plasma and erythrocyte membrane of Mg-deficient rats. (author abst.) |
|
|
|
Related Articles;
|
|
|
