Large Annular Purpura and Paraneoplastic Purpura in a Patient with Sjoegren's Syndrome and Cervical Cancer.

Accession number;00A0179414
Title;Large Annular Purpura and Paraneoplastic Purpura in a Patient with Sjoegren's Syndrome and Cervical Cancer.
Author; NAKAJIMA H (Kochi Medical School, Kochi, Jpn) IKEDA M (Kochi Medical School, Kochi, Jpn) YAMAMOTO Y (Kochi Medical School, Kochi, Jpn) KODAMA H (Kochi Medical School, Kochi, Jpn)
Journal Title;J Dermatol
Journal Code:Z0757A
ISSN:0385-2407
VOL.27;NO.1;PAGE.40-43(2000)
Figure&Table&Reference;FIG.4, REF.18
Pub. Country;Japan
Language;English
Abstract;We report a 79-year-old female with anaphylactoid purpura on her legs and unusual large annular purpura on the trunk. Histopathological characteristics of leukocytoclastic vasculitis were observed in the upper and middle dermis of both types of skin lesions. She was complicated by Sjoegren's syndrome and advanced cervical cancer. The annular purpura spontaneously resolved in a week and did not recur. However, the anaphylactoid purpura relapsed more frequently and spread more widely following the elevation of her serum SCC antigen levels from the onset of purpura until her death. We consider that the characteristic annular configuration was caused by the complication of Sjoegren's syndrome and that the recurrent anaphylactoid purpura indicated paraneoplastic vasculitis primarily caused by the tumor specific protein immune complexes. Complication by Sjoegren's syndrome many also play a role in the development of allergic vasculitis. (author abst.)
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