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Accession number;00A0196004
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| Title;Inhibitory effects of dietary foods on colon carcinogenesis and cancer control. |
| Author;
TAZAWA KENJI
(Toyama Med. and Pharm. Univ., Fac. of Med.)
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Journal Title;Eastern Medicine
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Journal Code:L0095A
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ISSN:0911-7768
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VOL.15;NO.4;PAGE.23-31(1999)
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| Figure&Table&Reference;TBL.5, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Dietary fiber is described as the proportion of plant foods not digested in the human small intestine. Among the various kinds of pectin, apple pectin exerts a bacteriostatic action and therefore may change the composition of the intestinal flora. The diet supplemented with 20% apple pectin significantly decreased the number and the incidence of AOM-induced colon tumors in rats. The prostaglandin E2 (PGE2) level in the distal colonic mucosa and blood of portal vein was lower in rats fed 20% pectin than those fed the basal diet. The ability of apple pectin to decrease PGE2 was dose-dependent and those results suggest an anti-inflammatory effect in the bowel. Rats fed apple pectin showed a significantly lower incidence of hepatic metastasis than those fed the basal diet. To determine whether the anti-inflammatory effect of Lactobacillus on hepatic metastasis model same as apple pectin, Lactobacillus casei was selected. Metastatic nodules were significantly reduced, especially in the group receiving pretreatment. Apple pectic oligosaccharides with small molecular weights showed highly inhibitory effects on hypoxanthinxanthin oxidase and ferrous sulfate-hydrogen peroxide. The scavenging activity of apple pectic oligosaccharides was suitable and accelerated at high temperatures (120.DEG.C., 30min.). In conclusion, apple pectin has a scavenger effect in the intestinal digestion and portal circulation system as an anti-inflammatory foods. Dietary fibers like pectin, and Lactobacillus have very important function in intestinal tract as anti-inflammatory foods. (author abst.) |
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