Control of hostility by means of DHA.
|
Accession number;00A0196005
|
| Title;Control of hostility by means of DHA. |
| Author;
HAMAZAKI TOMOHITO
(Res. Inst. of Wakan-Yaku, Toyama Med. and Pharm. Univ.)
|
Journal Title;Eastern Medicine
|
Journal Code:L0095A
|
ISSN:0911-7768
|
|
VOL.15;NO.4;PAGE.33-39(1999)
|
| Figure&Table&Reference;FIG.5, TBL.1, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The brain contains as exceptionally large quantity of membranes and therefore has an abundance of phospholipids, which are a major structural component of membranes. Since phospholipids in the brain contain a remarkably large amount of docosahexanoic acid (DHA, n-3 series), an essential fatty acid, DHA deficiencies have various effects on brain and nerve, function, including changes in behavior and mental capacity. DHA can be synthesized from .ALPHA.-lynolenic acid, which is from the same n-3 series of fatty acids. According to Okuyama et al., rats fed with zisu oil (oleum perillae) containing about 60% .ALPHA.-lynolenic acid had a superior capacity for learning (evaluated by light-dark discrimination) than n-3 fatty acid deficient rats. However, when the total number of correct responses (the animal receives food as a reward for pressing a pedal) and incorrect responses was examined, the number of responses made by the n-3 deficient rats was found to be higher than that of the rats fed the zisu oil. By the 25th learning trial, both groups should have been able to accurately discriminate between light and dark. However, the total number of responses made by the n-3 fatty acid deficient rats was 50% higher than that of the rats fed zisu oil, for both SHR and Wistar Kyoto rats. This result suggests that the n-3 fatty acid deficient rats could not resist the impulse to press a pedal, even if the animals knew that the response was incorrect. Moreover, differences in the ingestion rate of n-3 fatty acids and linolenic acid have been shown to cause changes in behavior and sensitivity to psychotropic drugs in rats. Among school children aged 6-12 years old, those who experience problems in behavior, sensation and sleep have been shown to have a lower level of n-3 fatty acids in their plasma phospholipids than that of a control group.... (author abst.) |
|
|
|
Related Articles;
|
|
