A Familial Parkinsonism Presenting with Dementia, Freezing Gait, Marked Wearing off Phenomenon, and Frontal Atrophy.
|
Accession number;00A0222255
|
| Title;A Familial Parkinsonism Presenting with Dementia, Freezing Gait, Marked Wearing off Phenomenon, and Frontal Atrophy. |
| Author;
YUASA TATSUHIKO
(Kokuritsu Seishin Shinkei Senta Konodai Byoin)
NISHIMIYA JIN
(Kokuritsu Seishin Shinkei Senta Konodai Byoin)
YOSHINO HIDE
(Kokuritsu Seishin Shinkei Senta Konodai Byoin)
|
Journal Title;Japanese Journal of National Medical Services
|
Journal Code:F0707A
|
ISSN:0021-1699
|
|
VOL.54;NO.1;PAGE.21-26(2000)
|
| Figure&Table&Reference;FIG.4, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In this report we present a family with late onset of parkinsonism, characterized by clinical features of freezing gait, wearing-off phenomenon, dementia, and frontal lobe atrophy. The father was said to have the same disease as his sons who showed Parkinson's symptoms starting at late 60 's. Anti-Parkinson's drugs showed an improvement in their Parkinsonian symptoms, but only to a slight degree. A marked wearing-off phenomenon followed after the combination therapy of several anti-Parkinsonian drugs. In recent years heredofamilial cases of Parkinson's disease and/or parkinsonisms drew attention in conjunction with gene mutations, and the Parkinson-related proteins, .ALPHA.-synuclein and the Parkin, were found to be related to chromosome 4q in one of the autosomal dominant types of parkinsonism and to chromosome 6q 25-27 in autosomal recessive juvenile parkinsonism, respectively. Although most of the cases of familial parkinsonism including familial cases of diffuse Lewy body disease are unknown etiology yet, a peculiar cases with balloned neurons were reported by Mizutani with 17-chromosome linked parkinsonism and frontotemporal dementia. The cases presented here are such one of familial cases as yet to be determined the etiology, but from a clinical point of view we suspected this family to have parkinsonism of the type described by Mizutani. (author abst.) |
|
|
|
Related Articles;
|
|
