Assessment of new cephem antibiotics cefoselis in mandibular tissue.
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Accession number;00A0360409
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| Title;Assessment of new cephem antibiotics cefoselis in mandibular tissue. |
| Author;
NAKAGAWA KIYOMASA
(Sch. of Med., Kanazawa Univ.)
KURIYAMA TOMOARI
(Sch. of Med., Kanazawa Univ.)
YAMAMOTO ETSUHIDE
(Sch. of Med., Kanazawa Univ.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.3;PAGE.191-194(2000)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.28 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A clinical investigation of a new cephem antibiotic, cefoselis (CFSL), was carried out. The tissue concentration of this drug was examined in plasma, gingiva, and cortical bone of mandible. Intravenous injection of 1 g CFSL was administered for 60 minutes to 10 volunteer patients. Assessment was completed in 9 patients with 1 drop out. The mean value of plasma concentration was 32.6.MU.g/mL and ranged from 22.0 to 46.0.MU.g/mL immediately after injection. However, the mean concentration value was 18.3.MU.g/mL and ranged from 8.82 to 29.2.MU.g/mL one hour after injection. The half time noted was 79.05 minutes. The mean value of mandibular gingiva concentration was 17.3.MU.g/g and ranged from 8.34 to 27.10.MU.g/g one hour after injection. The overall concentration ratio of gingiva/plasma was 99.5%. Alternatively, the mean value of mandibular cortical concentration was 2.8.MU.g/g and ranged from 0.45 to 7.25.MU.g/g one hour after injection. The overall concentration ratio of the mandible/plasma was 21.2%. These results indicate a superior value in tissue concentration of CFSL compared to other cephems, and no major postinjection complication. Furthermore, the present study suggests that CFSL attains a high mandibular tissue concentration. In conclusion, CFSL is effective in the treatment of oral and maxillofacial infections. (author abst.) |
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