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Accession number;00A0360410
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| Title;Clinical studies of cefozopran in children with acute respiratory infection. |
| Author;
SAKATA HIROSHI
(Asahikawa Kosei Hosp.)
MARUYAMA SHIZUO
(Asahikawa Kosei Hosp.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.3;PAGE.195-198(2000)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Between January 1999 and August 1999, 87 children were treated with cefozopran (CZOP), ages ranging from 5 months to 13 years. CZOP was administered by intravenous injection every 8 hours 54.6 to 78.9 mg/kg in a daily dose for 2 to 10 days. Out of 87 patients, in 42 were detected pathogenic organisms, including 34 with bronchopneumonia and 8 with both bronchopneumonia and acute otitis media. These 42 patients were evaluated for clinical and bacteriological efficacy. The clinical efficacy rate was 100%. The bacteriological eradication rates for Haemophilus influenzae and Streptococcus pneumoniae were 92.3% (24/26) and 85.7% (18/21). Five patients had pneumonia or acute otitis media 7 to 14 days after the cessation of CZOP treatment. The clinical efficacy rate for an additional 29 patients who were suspected of bacterial infection but in whom pathogenic organisms were not detected, was 100%. Safety investigations were performed for all 87 subjects. Diarrhea was observed in 4 infants (4.6%). (author abst.) |
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