Science Links Japan | Relation between interleukin-1.BETA. messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori.

Relation between interleukin-1.BETA. messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori.

Accession number;00A0234920

Title;Relation between interleukin-1.BETA. messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori.

Author; WANG M (Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn) FURUTA T (Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn) TAKASHIMA M (Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn) FUTAMI H (Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn) SHIRAI N (Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn) HANAI H (Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn) KANEKO E (Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn)

Journal Title;J Gastroenterol

Journal Code:Z0748A

ISSN:0944-1174

VOL.34;NO.Supplement 11;PAGE.10-17(1999)

Figure&Table&Reference;FIG.9, REF.40

Pub. Country;Japan

Language;English

Abstract;The effects of Helicobacter pylori infection on gastric acid secretion has not been clarified. The aim of this study was to elucidate the effects of H. pylori infection on gastric juice pH in relation to gene expression of interleukin-1.BETA. (IL-1.BETA.), which is reported to inhibit gastric acid secretion. Gastric juice pH and serum gastrin levels were measured in patients with peptic ulcer disease. The amount of IL-1.BETA. mRNA in gastric fundic gland mucosa was also measured by a competitive reverse transcription-polymerase chain reaction method. These parameters were determined before and after treatment with lansoprazole and amoxicillin. Before treatment a significant positive relation was observed between the amount of IL-1.BETA. mRNA in gastric fundic gland mucosa and gastric juice pH. After treatment significant decreases in the amount of IL-1.BETA. mRNA, gastric juice pH, and serum gastrin levels were observed in patients with eradication of H. pylori, whereas no significant changes were observed in patients without eradication. These results suggest that H. pylori infection induces IL-1 .BETA. and suppresses acid secretion, resulting in increases in gastric juice pH and serum gastrin levels. Eradication of H. pylori decreases IL-1.BETA. induction, resulting in an increase in gastric juice acidity and normalization of serum gastrin levels. (author abst.)

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