Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori.
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Accession number;00A0234935
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| Title;Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori. |
| Author;
GOTODA T
(National Cancer Center Hospital, Tokyo, Jpn)
SAITO D
(National Cancer Center Hospital, Tokyo, Jpn)
KONDO H
(National Cancer Center Hospital, Tokyo, Jpn)
ONO H
(National Cancer Center Hospital, Tokyo, Jpn)
ODA I
(National Cancer Center Hospital, Tokyo, Jpn)
FUJISHIRO M
(National Cancer Center Hospital, Tokyo, Jpn)
YAMAGUCHI H
(National Cancer Center Hospital, Tokyo, Jpn)
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Journal Title;J Gastroenterol
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Journal Code:Z0748A
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ISSN:0944-1174
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VOL.34;NO.Supplement 11;PAGE.91-96(1999)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Although epidemiological studies strongly suggest an association between Helicobacter pylori infection and gastric carcinogenesis via a multistage process, a causal link between them has not been demonstrated. We evaluated the endoscopic and histological changes of gastric adenoma, which is considered a premalignant condition, after eradication of H. pylori. Thirty-five H. pylori-infected patients with gastric adenoma were treated with triple therapy (lansoprazole 30mg/day, clarithromycin 400 mg/day, and amoxicillin 1500mg/day) for 1 week. Of these 35 patients, 30 (86%) exhibited no H. pylori by culture or histology after the therapy. Of the 30 gastric adenomas, 7 decreased in size endoscopically; three gastric adenomas especially showed apparent remission, although histological cure in these three patients was not apparent. Our results suggest that removal of H. pylori infection may only mask a gastric adenoma endoscopically owing to the change around the gastric mucosa. (author abst.) |
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