The Effect of Intraocular Lidocaine in White Rabbit Eyes.

Accession number;00A0446397
Title;The Effect of Intraocular Lidocaine in White Rabbit Eyes.
Author; NISHIDE TADAYUKI (Yokohama City Univ., Sch. of Med.) KADONOSONO KAZUAKI (Yokohama City Univ., Sch. of Med.) ITO NORIHIKO (Yokohama City Univ., Sch. of Med.) YAZAMA FUTOSHI (Yokohama City Univ., Sch. of Med.) ENDO YOKO (Yokohama City Univ., Sch. of Med.) SAWADA HAJIME (Yokohama City Univ., Sch. of Med.) ONO SHIGEAKI (Yokohama City Univ., Sch. of Med.)
Journal Title;Journal of Japanese Ophthalmological Society
Journal Code:Z0666A
ISSN:0029-0203
VOL.104;NO.4;PAGE.214-220(2000)
Figure&Table&Reference;FIG.9, TBL.2, REF.7
Pub. Country;Japan
Language;Japanese
Abstract;Purpose: Recently, intraocular lidocaine anesthesia has been used in cataract surgery. We studied the toxicity of intraocular unpreserved lidocaine for corneal endothelial cell and retina using Japanese white rabbits. Method: They were divided into two groups. One group was injected intracamerally and the other group was injected intravitreally with 0.2 ml of unpreserved lidocaine of 0%, 0.02%, 0.2%, or 2% concentration. The number of corneal endothelial cells was measured I week after the injection. The rabbits were killed after measurements, and their corneas were studied histologically. The retina was examined by electroretinogram from before the injection through 1 week after the injection. Results: There was no significant change in number of corneal endothelial cells after injection of 0.2% lidocaine. However, histological abnormality was seen in corneal endothelial cells after 2% lidocaine injection. There was also significant change in electroretinogram with 2% lidocaine injection . No histological abnormality was seen in the retina 1 week after the injection. Conclusion: The rabbit cornea and retina manifested no serious changes after the injection of lidocaine at less than 0.2% concentration functionally and histologically. (author abst.)
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