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Accession number;00A0204399
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| Title;Molecular Mechanisms of Neuronal Alignment in the Cerebral Cortex and Cerebellar Cortex. |
| Author;
NAKAJIMA KAZUNORI
(Tokyojikeikaiidai Dnaiken)
MIKOSHIBA KATSUHIKO
(Inst. of Med. Sci., Univ. of Tokyo)
OGAWA MASAHARU
(Inst. of Physical and Chemical Res.)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.45;NO.3;PAGE.241-247(2000)
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| Figure&Table&Reference;REF.27 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The mammalian brain cortex shows a multilayered structure parallel to the brain surface. The mechanism by which each of the nerve cells moves from the generation field to arrange in order, has been clarified from some of the mutant mouse analysis. In the present report, recent knowledge and information are introduced, focusing on the reelin and Disabled 1 (Dab1). Dab1 is produced in the moving neuroblasts and plays a role to mediate reelin signal extracellularly. When these factors are lost, inversion of the cortex structure in the cerebrum occurrs, while in the cerebellum where purkinje cells should originally range in one layer, these remain in the deep region. |
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