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Accession number;00A0204410
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| Title;Molecular Mechanisms that Regulate Neuron Network Formation in PNS. |
| Author;
FUJISAWA HAJIME
(Nagoya Univ., Grad. Sch.)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.45;NO.3;PAGE.323-328(2000)
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| Figure&Table&Reference;FIG.3, REF.36 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Since the peripheral nerve circuit shows a very orderly, standardized pattern, by the good model experiment system for making clear the nerve circuit formation mechanism, many of the research have been made, although the molecular mechanism to control the peripheral nerve circuit formation has not yet been elucidated. Neuropilin 1 is a receptor of the axon repulsion factor semaphorin D. In the neuropirin 1 gene function destruction mouse and semaphorin D gene function destruction mouse, a sharp disturbance in traveling, bundling and projection was shown. It became evident that the semaphorin D signal intermediated by neuropilin 1 limited elongation direction of the peripheral nerve axon and was an important molecular mechanism producing an orderly segmental peripheral nerve circuit. |
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